Aug 21, 2019:
New publication in Nature Communications on the
PI3K-SH3 amyloid fibril structure by Cryo-EM.
see here.
Aug 7, 2019:
New DireX Version 0.7.1. Added a turbo mode, which is much faster (but less accurate).
Download here.
Sep 10, 2017:
New publication in Science on the Abeta(1-42) fibril structure.
see here.
Sep 1, 2017:
We have new job openings for postdocs
and PhD students,
see here.
Jul 10, 2017:
Congratulations to Michaela, Amudha, and
Tatjana on their
successful PhD Defenses!
Dec 4, 2015:
Congratulations to Dennis on his
successfull PhD Defense!
Nov 22, 2015:
New publications on our protein structure refinement
method and CASP11 results.
Feb 3, 2015:
Congratulations to Zhe on his
successfull PhD Defense!
Video Lectures
VISDEM Density Sharpening
The VISDEM method improves the visualization of density maps by using general
statistical information about proteins for the sharpening process. In particular, the packing
density of atoms is highly similar between different proteins, which allows for building a
pseudo-atomic model to approximate the true mass distribution. From this model the radial
structure factor and density value histogram are estimated and applied as constraints to
the 3D reconstruction in reciprocal- and real-space, respectively.
Real-space model refinement with DireX
This video introduces the real-space refinement program DireX, which has been developed to refine protein structures against low-resolution density maps from Cryo-EM or X-ray crystallography.