DireX - Low-resolution Structure Refinement
DireX performs efficient geometry-based conformational sampling of protein
structures under experimental restraints. It combines prior structural
information with experimental data through the Deformable Elastic Network
(DEN) approach which drastically reduces over-fitting.
Experimental restraints which can be used in the current version are:
- (Electron) Density Map (obtained e.g. from X-ray crystallography, Electron microscopy, or SAXS)
- Distance Restraints (e.g. from NMR or FRET experiments)
To get a first impression: Watch a movie
of fitting Elongation
factor 2 (EF-2) into an 8 Å density map.