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DireX - Low-resolution Structure Refinement



DireX performs efficient geometry-based conformational sampling of protein structures under experimental restraints. It combines prior structural information with experimental data through the Deformable Elastic Network (DEN) approach which drastically reduces over-fitting.

Experimental restraints which can be used in the current version are:

To get a first impression: Watch a movie of fitting Elongation factor 2 (EF-2) into an 8 Å density map.


Upcoming DireX Tutorials:
* 8-12 Jan 2014, Urbana-Champaign, Illinois. Workshop on Cryo-EM Modeling Based on X-ray Crysta llography. See more details here.
* Jul 28 – 30, 2014. Shanghai, China. Kuo Symposium on 3D Cryo-EM Molecular Imaging.
* 31 Aug - 9 Sep 2014, EMBL Heidelberg, EMBO Practical Course Cryo-Electron Microscopy and 3D Image Processing. More information here

ef2